Prophylactic antimalarial effects of Cymbopogon citratus (DC.) Stapf (Poaceae) in a mouse model of Plasmodium berghei ANKA infection: normalisation of haematological and serum biochemical status

Ethnopharmacological relevance: Cymbopogon citratus (DC.) Stapf (Poaceae) is a medicinal plant known for its antimalarial, antipyretic and antifatigue activities in Cameroonian folk medicine. Aim of the study: The aim this work was to evaluate prophylactic antimalarial effects decoction prepared from leaves on Plasmodium berghei ANKA infection mice investigate action haematological serum biochemical status. Materials methods: Swiss were treated with leaf (25, 50, 100 200 mg/kg) later inoculated ANKA. activity evaluated by determining parasitaemia, percentage chemosuppression, body weight, temperature, food water intake pretreated parasitised mice. possible ameliorative malaria associated changes also assessed. Results: exhibited 85.32% chemotherapeutic ranged 56.88 – maximum effect observed at highest experimental dose. It significantly inhibited parasitaemia (P < 0.001) compared negative control group. Interestingly, treatment restored modified status distilled water-treated Conclusion: results assay indicated that has normalised aberrations generated malaria. Hence, represents promising source new agents.